Multiple Sclerosis Susceptibility Genes: Associations with Relapse Severity and Recovery

Multiple Sclerosis Susceptibility Genes: Associations with Relapse Severity and Recovery

OBJECTIVE Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes are associated with these attack features or with the risk of a second attack. METHODS 503 white subjects evaluated within a year of MS onset were included in the study. The severity of and recovery from the first two attacks w...

Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity

Multiple sclerosis (MS) is an autoimmune neuro-inflammatory disease arising from complex interactions of genetic, epigenetic, and environmental factors. Variations in genes of some microRNAs--key post-transcriptional regulators of many genes--can influence microRNAs expression/function and contribute to MS via expression changes of protein-coding target mRNA genes. We performed an association s...

Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis

Correlation between Acoustic Parameters and Disease Severity and Duration in Patients with Multiple Sclerosis

Background: Since in multiple sclerosis (MS), changes in speech and voice quality often precede other signs and symptoms; early diagnosis of these changes is necessary. In this study, an acoustic examination of phonation subsystem was performed. Due to the progressive nature of multiple sclerosis, the aim of this study was to examine the correlation between acoustic parameters ...

Improvement in relapse recovery with peginterferon beta-1a in patients with multiple sclerosis

BACKGROUND Subcutaneous peginterferon beta-1a every 2 weeks significantly affects clinical outcomes in patients with relapsing-remitting multiple sclerosis (RRMS). OBJECTIVES To explore relationships between relapses and worsening of disability in patients with RRMS, and assess the treatment effect of peginterferon beta-1a on relapse recovery. METHODS Post-hoc analysis of the 2-year, random...